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Type 1‐like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity
Author(s) -
Brandenburg A.H.,
Kleinjan A.,
van het Land B.,
Moll H.A.,
Timmerman H.H.,
de Swart R.L.,
Neijens H.J.,
Fokkens W.,
Osterhaus A.D.M.E.
Publication year - 2000
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/1096-9071(200010)62:2<267::aid-jmv20>3.0.co;2-8
Subject(s) - immune system , immunology , virus , respiratory system , peripheral blood mononuclear cell , medicine , biology , virology , in vitro , biochemistry
The immunological response of infants younger than six months to infection with respiratory syncytial virus (RSV) was studied in relation to clinical severity. IL‐6 and IL‐8 were found more frequently and at higher levels in the plasma samples of more severely ill patients and no significant differences were found in the levels of cytokines differentiating between Type 1 and Type 2 responses. Cellular infiltrates in nasopharyngeal washings consisted mainly of polymorphonuclear granulocytes and monocytes. Eosinophils, IgE positive cells and tryptase positive cells were found sporadically. Analyses of RSV stimulated T cell cultures established from peripheral blood mononuclear cells, for intracellular and secreted cytokines showed that, irrespective of clinical severity, the responses were dominated by the production of IFN‐γ, and that only low levels of IL‐4 and IL‐10 were detectable. Collectively these data do not indicate an association between clinical severity and a Type 2‐like T cell response. J. Med. Virol. 62:267–277, 2000. © 2000 Wiley‐Liss, Inc.