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Resistance of recent measles virus wild‐type isolates to antibody‐mediated neutralization by vaccinees with antibody
Author(s) -
Klingele Matthias,
Hartter Heike K.,
Adu Festus,
Ammerlaan Wim,
Ikusika Wole,
Muller Claude P.
Publication year - 2000
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/1096-9071(200009)62:1<91::aid-jmv14>3.0.co;2-b
Subject(s) - neutralization , virology , measles , measles virus , neutralizing antibody , virus , antibody , immunity , biology , titer , vaccination , immunology , immune system
The neutralization capacity of sera from Luxembourgian adolescent vaccinees and from Nigerian women with measles‐induced immunity to a number of measles virus strains was compared. Although both cohorts were matched for their hemagglutination inhibition and standard neutralization titers, 12 of the 22 late convalescent sera, and only 6 of 24 vaccinees neutralized all viruses. Similarly, only 2 of 20 viruses were not neutralized by at least 75% of late convalescent sera, in comparison to 10 of 20 viruses that resisted neutralization by at least 75% of the vaccinees. The more resistant viruses were not limited to a certain clade. One Nigerian virus was resistant to neutralization by 30% of the late convalescent women and by 75% of vaccinees. These results suggest that qualitative differences in neutralizing antibodies may reduce further protection of infants by passively acquired immunity against wild‐type viruses when vaccinated girls become mothers. J. Med. Virol. 62:91–98, 2000. © 2000 Wiley‐Liss, Inc.