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Human herpesvirus 8‐encoded interleukin‐6 homologue (viral IL‐6) induces endogenous human IL‐6 secretion
Author(s) -
Mori Yasuko,
Nishimoto Norihiro,
Ohno Mika,
Inagi Reiko,
Dhepakson Panadda,
Amou Kiyoko,
Yoshizaki Kazuyuki,
Yamanishi Koichi
Publication year - 2000
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/1096-9071(200007)61:3<332::aid-jmv8>3.0.co;2-3
Subject(s) - endogeny , secretion , reverse transcriptase , virology , pathogenesis , biology , reverse transcription polymerase chain reaction , interleukin , raji cell , polymerase chain reaction , virus , gene , immunology , messenger rna , cytokine , genetics , biochemistry , endocrinology
We found that human herpesvirus 8‐encoded IL‐6 (vIL‐6) induced endogenous human IL‐6 (huIL‐6) secretion from various cell lines (MT‐4, THP‐1, U937, Raji, and CESS) including patients with multicentric Castleman's disease. Especially, in MT‐4 cells, huIL‐6 was enhanced with vIL‐6 by 30‐fold compared with that of control. In addition, reverse transcriptase‐polymerase chain reaction confirmed that vIL‐6 induced huIL‐6 expression in MT‐4 cells. Our novel finding of the huIL‐6 induction by vIL‐6 indicates that vIL‐6 may play a significant role in the pathogenesis of HHV‐8 associated diseases. J. Med. Virol. 61:332–335, 2000. © 2000 Wiley‐Liss, Inc.