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Quantitative relationship between HBeAg and DNA polymerase activity in sera from patients with chronic active hepatitis during a three‐month period
Author(s) -
Heijtink R. A.,
van der Waart M.,
Weimar W.,
Schalm S. W.,
Masurel N.
Publication year - 1980
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/1096-9071(1980)5:4<295::aid-jmv1890050405>3.0.co;2-5
Subject(s) - hbeag , virology , dna polymerase , dna , hepatitis , polymerase chain reaction , hepatitis b virus dna polymerase , chronic hepatitis , polymerase , medicine , immunology , biology , virus , hepatitis b virus , hbsag , gene , genetics
In eight patients with biopsy‐confirmed chronic active hepatitis (CAH), hepatitis B e antigen (HBeAg) levels and DNA polymerase (DNA‐P) activity were assayed three times a week for six weeks and once a week for another six weeks. HBeAg levels were rather constant, whereas DNA‐P activity fluctuated. No correlation was observed between the quantities of HBeAg and DNA‐P activity. An unexpected fluctuation in DNA‐P activity was noted in all patients after an influenza vaccination.