Premium
Anti‐DNA, anti‐HBc correlations with RIA‐detected HBeAg and anti‐HBe in chronic HBsAg carriers
Author(s) -
Villarejos VíCtor M.,
AndersenVisoná Kirsten,
Serra C. Jaime,
Frösner Gert G.,
Deinhardt Friedrich
Publication year - 1980
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/1096-9071(1980)5:4<265::aid-jmv1890050402>3.0.co;2-n
Subject(s) - hbeag , virology , hbsag , medicine , hepatitis b antigens , virus , hepatitis b virus
The interrelations of 1) antibody to hepatitis B core antigen (HBcAg) — anti‐HBc; 2) single‐stranded DNA‐binding antibodies (anti‐DN A); and 3) the e‐antigen/antibody system — hepatitis B e antigen (HBeAg) and antibody (anti‐HBe), were studied in 150 hepatitis B surface antigen (HBsAg) carriers, in 43 of whom diagnostic liver biopsies had been performed. There was a good correlation between titers of anti‐HBc and anti‐DN A, regarded as indicators of viral and pathological activity, respectively, as well as between levels of these two antibodies and the presence of HBeAg or anti‐HBE as detected by radio‐immune assay (RIA). In general, HBeAg‐positive carriers showed high anti‐HBc and high anti‐DNA titers, while the carriers positive for anti‐HBe had low titers of both. These findings were in accord with the histopathological results. The three serologic parameters, anti‐HBc, anti‐DNA, and e‐antigen/anti‐body, should together prove useful for the evaluation of the clinical status of chronic HBsAg carriers.