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Intravenous gammaglobulin‐associated acute renal failure
Author(s) -
Gupta N.,
Ahmed I.,
NisselHorowitz S.,
Patel D.,
Mehrotra B.
Publication year - 2001
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(200102)66:2<151::aid-ajh1035>3.0.co;2-q
Subject(s) - medicine , complication , gamma globulin , pathophysiology , intensive care medicine , immunology , antibody
Intravenous gammaglobulins are used for the treatment of various auto‐immune hematological disorders. Renal failure is a relatively rare, but an increasingly recognized side effect of gammaglobulin therapy. Although the renal failure is usually reversible, renal replacement therapy is required occasionally. A high index of suspicion, early recognition and appropriate intervention can prevent this complication. We herewith describe two patients with an immune hematological disorder, who developed acute renal failure after treatment with intravenous gammaglobulins. A brief review of the possible risk factors, pathophysiology and management of this complication is provided. Am. J. Hematol. 66:151–152, 2001. © 2001 Wiley‐Liss, Inc.