Premium
Familial nasal NK/T‐cell lymphoma and pesticide use
Author(s) -
Kojya Shizuo,
Matsumura Jun,
Ting Li,
Hongyo Tadashi,
Inazawa Johji,
Kirihata Mitsunori,
Aozasa Katsuyuki
Publication year - 2001
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(200102)66:2<145::aid-ajh1033>3.0.co;2-v
Subject(s) - proband , lymphoma , peripheral blood , medicine , pesticide , disease , physiology , immunology , biology , pathology , mutation , genetics , gene , agronomy
Familial occurrence of nasal NK/T‐cell lymphoma (NNKTCL) in pesticide users is presented. The proband (71 years old, male) and son (39 years old) were both diagnosed with NNKTCL within interval of 26 months. Laboratory data showed slight anemia, with no abnormal cells in peripheral blood. They and their wives were farmers and used large amounts of pesticides (fungicides and insecticides) in the hothouse. NNKTCL did not develop in the wives. Proband's father was diagnosed with malignant lymphoma of the neck and died of the disease. Genetic analyses of the peripheral blood leukocytes and tumor tissues did not show p53 and k‐ras gene mutations and microsatellite instability. Metaphase cells from peripheral blood leukocytes bore specific marker chromosomes (father, 44XY,−14,−17,−18,−22,+2mar; son, 46XY,−17,+1mar). Environmental exposures to pesticides in conjunction with familial or genetic factors might increase the risk for NNKTCL. Am. J. Hematol. 66:145–147, 2001. © 2001 Wiley‐Liss, Inc.