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EBV‐associated perianal Hodgkin's disease in an HIV‐positive individual
Author(s) -
Sapp Michelle,
PerezOrdonez Bayardo,
Brenneman Fred,
Imrie Kevin,
MoravaProtzner Isabella,
Lim Megan S.
Publication year - 2001
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(200101)66:1<42::aid-ajh1006>3.0.co;2-v
Subject(s) - cd15 , lymphoma , pathology , medicine , reed–sternberg cell , biopsy , cd20 , population , cd30 , incidence (geometry) , disease , hodgkin lymphoma , biology , cd34 , genetics , physics , stem cell , environmental health , optics
Abstract Hodgkin's disease (HD) has a higher incidence in HIV‐positive individuals. It tends to occur at extranodal sites, frequently exhibits an unfavorable histological type with large numbers of neoplastic cells, and almost invariably harbors Epstein‐Barr Virus (EBV). We describe a case of a 33‐year‐old HIV‐positive man who presented with anal pain from a 4‐cm mass in the anorectal canal. He had no B symptoms or peripheral lymphadenopathy. A chest X‐ray was within normal limits. A biopsy showed an ulcerated mass composed of a mixed infiltrate of lymphocytes, plasma cells, eosinophils, and Reed‐Sternberg (RS) cells positive for CD15 and strongly positive for CD30. They were negative for CD45 and CD20. Numerous RS cells and lymphocytes were positive for EBV RNA using the EBER‐1 probe. This highly unusual presentation of HD may reflect the greater incidence of anorectal lymphoma and of extranodal HD in the HIV‐positive population. Am. J. Hematol. 66:42–45, 2001. © 2001 Wiley‐Liss, Inc.