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Lineage switch from acute myeloid leukemia to acute lymphoblastic leukemia: Report of an adult case and review of the literature
Author(s) -
Lounici A.,
ConyMakhoul P.,
Dubus P.,
Lacombe F.,
Merlio J.P.,
Reiffers J.
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(200012)65:4<319::aid-ajh13>3.0.co;2-1
Subject(s) - immunophenotyping , lineage (genetic) , gene rearrangement , fusion gene , karyotype , myeloid leukemia , medicine , cytogenetics , acute lymphocytic leukemia , leukemia , pathology , oncology , immunology , biology , lymphoblastic leukemia , gene , flow cytometry , genetics , chromosome
Lineage switch from AML to ALL is an extremely rare phenomenon, and we report the case of an adult diagnosed with AML at 46 years of age who relapsed with ALL. At initial diagnosis, blast cell morphology and immunophenotyping were consistent with the diagnosis of M4‐AML. Complete remission was achieved, and the patient underwent autologous BMT. At relapse, six months after ABMT, blast cells were different from those seen at initial diagnosis, for morphology (L2‐ALL), cytochemistry, and immunophenotyping. The karyotype was normal at both diagnosis and relapse. No evidence of bcr‐abl fusion genes was found by RT‐PCR. Monoclonal IgH and TCR γ gene rearrangement were evidenced by PCR analysis at relapse but not on blast cells at AML diagnosis. Am. J. Hematol. 65:319–321, 2000. © 2000 Wiley‐Liss, Inc.