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CD8‐depleted donor leukocyte transfusions for cytomegalovirus antigenemia in patient with acute lymphoblastic leukemia treated with allogeneic CD34 + cell transplantation
Author(s) -
Okumura Hirokazu,
Yoshida Takashi,
Takamatsu Hideyuki,
Mochizuki Yasuhiro,
Takeshima Minoru,
Ohtake Shigeki,
Ikeno Tsunehisa,
Nakamura Shinobu,
Nakao Shinji
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(200012)65:4<278::aid-ajh2>3.0.co;2-3
Subject(s) - ganciclovir , medicine , cd8 , cytomegalovirus , immunology , transplantation , cd34 , human leukocyte antigen , human cytomegalovirus , betaherpesvirinae , leukemia , herpesviridae , antigen , virus , viral disease , stem cell , biology , genetics
A 24‐year‐old man with acute lymphoblastic leukemia received an allogeneic CD34 + cell transplant from an HLA‐mismatched sibling because of refractory disease. The CD34 + cells were enriched by the immunomagnetic method. One month after the transplant his situation became complicated due to cytomegalovirus (CMV) antigenemia, which was resistant to treatment with ganciclovir. He was treated with CD8 + cell‐depleted donor lymphocyte transfusions (CD8‐depleted DLT). After CD8‐depleted DLT, the CMV antigenemia disappeared completely. This case report suggested that CD8‐depleted DLT was an effective therapy for CMV antigenemia after allogeneic CD34 + cell transplantation. Am. J. Hematol. 65:278–280, 2000. © 2000 Wiley‐Liss, Inc.