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Nonhepatosplenic γδ T‐cell lymphoma with initial testicular compromise
Author(s) -
Scolnik Mariano P.,
Burgos Rubén A.,
Paz Analía,
Weinreiter Mariela,
del Carmen Ardaiz María,
Bare Patricia,
Bayo Hanza María Carolina,
de Dios Soler Marcela A.,
Inés Narbaitz Marina,
Fernanda Palacios María,
Sasot Adhelma,
Huberman Ana,
Marta de E de Bracco María
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(200011)65:3<260::aid-ajh15>3.0.co;2-v
Subject(s) - t cell receptor , cd3 , lymphoma , cd8 , biology , gene rearrangement , cd5 , cd64 , t cell lymphoma , t cell , hepatosplenomegaly , flow cytometry , pathology , antigen , microbiology and biotechnology , immunology , medicine , gene , immune system , biochemistry , disease
We report here a case of nonhepatosplenic γδ T‐cell lymphoma with undescribed initial localization in testis, without hepatosplenomegaly or adenopathies, and subsequent development in the maxillary sinus. The maxillar mass biopsy revealed a T‐cell infiltration, and its immunologic characterization by flow cytometry showed a γδ T‐cell phenotype (CD45 + , CD3 + , CD2 + , TCR γδ + ), without expression of CD7, CD5, CD1a, TdT, CD4, CD8, TCR αβ, or NK antigens (CD16, CD56, and CD57). Clonal γ‐chain gene rearrangement by polymerase chain reaction (PCR) was detected in testicular and maxillar biopsies. Epstein‐Barr virus type 1 (EBV) sequences were detected by molecular biology in the biopsy material, suggesting that this oncogenic virus may play a role in the genesis of the clonal expansion of γδ T‐cells. The patient was initially treated with standard chemotherapeutic protocols, with poor response and aggressive course. Am. J. Hematol. 65:260–262, 2000. © 2000 Wiley‐Liss, Inc.