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T‐ALL with monoclonal gammopathy and hairy cell features
Author(s) -
Yetgin Sevgi,
Olcay Lale,
Yel Leman,
Tuncer Murat,
Tezcan İlhan,
Erdemli Esra,
Öner Ahmet Faik,
Behm Frederick G.
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(200010)65:2<166::aid-ajh13>3.0.co;2-#
Subject(s) - monoclonal gammopathy , monoclonal gammopathy of undetermined significance , paraproteinemias , medicine , monoclonal , monoclonal antibody , immunology , antibody
The presented case is a boy with T‐cell acute lymphoblastic leukemia (ALL) with hairy cell (HC) features and monoclonal gammopathy. The disease process had an acute onset and followed a rapid, progressive course. The patient had minimal splenomegaly and bicytopenia, but the bone marrow displayed increased numbers of reticulin fibers. The blasts were positive for tartrate‐resistant acid phosphatase (TRAP) and CD11c. Molecular analysis revealed rearrangement of immunoglobulin heavy chain genes and a rearranged T‐cell receptor (TcRβ) beta gene. The patient responded to conventional ALL therapy. Acute T‐cell ALL with HC features in childhood has not been reported previously, either alone or in association with monoclonal gammopathy. We propose “T‐ALL with hairy cell features” to describe this case. Am. J. Hematol. 65:166–170, 2000. © 2000 Wiley‐Liss, Inc.