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Primary effusion lymphoma with B‐cell phenotype
Author(s) -
Iwahashi Masahito,
Iida Syuji,
Sako Shigeki,
Inoue Souichi,
Kikuchi Hiroshi,
Otsuka Eiichi,
Nasu Masaru
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(200008)64:4<317::aid-ajh15>3.0.co;2-i
Subject(s) - primary effusion lymphoma , lymphoma , effusion , cd19 , immunohistochemistry , medicine , cd20 , prednisolone , pathology , b cell lymphoma , gene rearrangement , immunoglobulin light chain , phenotype , antibody , immunology , biology , gene , surgery , biochemistry
We describe here a case of primary effusion lymphoma that occurred in a 78‐year‐old woman. She was successively treated with prednisolone but died 15 months after the diagnosis of primary effusion lymphoma. The immunohistochemistry revealed the neoplastic cells to be CD19 + , CD20 + , CD21 + , Sm‐Ig + , and HLA‐DR + . This patient exhibited clonal IgH and clonal κ light chain gene rearrangement, indicating a B‐cell origin. The present case was distinguished from the majority cases of HHV‐8‐positive primary effusion lymphoma. Here we present clinical details of response to therapy in this case. Am. J. Hematol. 64:317–318, 2000. © 2000 Wiley‐Liss, Inc.