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Ruptured Klebsiella pneumoniae liver abscess after high‐dose cyclophosphamide for severe aplastic anemia
Author(s) -
Lee JeJung,
Kim HyeoungJoon,
Chung IkJoo,
Kook Hoon,
Park MooRim,
Kim ChanJong,
Shin DongHyeon,
Hwang TaiJu
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(200007)64:3<218::aid-ajh15>3.0.co;2-m
Subject(s) - medicine , aplastic anemia , cyclophosphamide , liver abscess , sepsis , surgery , anemia , abscess , abdominal pain , bone marrow failure , gastroenterology , bone marrow , chemotherapy , haematopoiesis , stem cell , biology , genetics
A 19‐year‐old woman with severe aplastic anemia who had previously failed antithymocyte globulin/cyclosporine A received high‐dose cyclophosphamide without bone marrow rescue. On day +14, she complained of right upper quadrant abdominal pain and fever. A CT scan of the abdomen showed multiple liver abscesses with rupture and Klebsiella pneumoniae was isolated from blood. In spite of aggressive antibiotic therapy, she rapidly deteriorated and died of overwhelming sepsis. To our knowledge, our patient is the first case of fatal ruptured liver abscess after high‐dose cyclophosphamide in a patient with severe aplastic anemia. Am. J. Hematol. 64:218–220, 2000. © 2000 Wiley‐Liss, Inc.