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Co‐existence of cutaneous T‐cell lymphoma and B hairy cell leukemia
Author(s) -
Paolini Rossella,
Poletti Alessandro,
Ramazzina Emilio,
Menin Chiara,
Santacatterina Maria,
Montagna Marco,
Bonaldi Laura,
Del Mistro Annarosa,
Zamboni Sergio,
D'Andrea Emma
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(200007)64:3<197::aid-ajh10>3.0.co;2-f
Subject(s) - hairy cell leukemia , leukemia , lymphoma , medicine , cancer research , dermatology , immunology
A primary cutaneous form of peripheral T‐cell lymphoma (PTCL) and a low grade B‐cell non‐Hodgkin's lymphoma that was classified as a variant of hairy cell leukemia (HCL) were simultaneously diagnosed in a 79‐year‐old woman by both phenotypic and genotypic analyses. The coexistence of a T‐ and B‐cell lymphoma in the same patient is rare, and, to our knowledge, this particular association has not been previously described. The patient was referred to our Department for evaluation of multiple cutaneous itchy, reddish plaques; laboratory analyses disclosed a lymphocytosis, that presented 6 years earlier. A bone marrow aspirate showed a 50% B‐cell interstitial infiltrate, while a skin biopsy surprisingly revealed a PTCL. Clonality of both neoplastic processes was assessed by Southern blot analysis. The indolent clinical course of the cutaneous disease, and the low and stable number of circulating neoplastic T cells supported the diagnosis of a mycosis fungoides (MF)‐like PTCL. Possible oncogenic events and/or putative underlying viral infections which could have played a role in the occurrence of B‐ and T‐cell non‐Hodgkin's lymphomas in the same patient are discussed. Am. J. Hematol. 64:197–202, 2000. © 2000 Wiley‐Liss, Inc.