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Thrombotic Thrombocytopenic Purpura and Relapes: Why do case series differ?
Author(s) -
Porta Camillo,
Centurioni Riccardo,
Gugliotta Luigi,
BobbioPhllavicini Enrico,
Billio Atto
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(199607)52:3<215::aid-ajh2830520303>3.0.co;2-9
Subject(s) - medicine , thrombotic thrombocytopenic purpura , incidence (geometry) , retrospective cohort study , thrombocytopenic purpura , series (stratigraphy) , pediatrics , hematology , purpura (gastropod) , surgery , dermatology , platelet , paleontology , ecology , physics , optics , biology
We examined the retrospective case series of the Itallan Cooperative Group to determine the incidence of relapes in TTP patients. Of 60 patients who have crossed the 10‐year threshold from the first episode, Only 9 (15%) relapsed during that period, a figure far lower than that reported recently. Such difference is hardly explainable on the basis of our current knowledge of the biological behaviour of TTP. Furthermore, we unsuccessfully analyzed the treatment performed in each of our relapsed patients, in search of some element that could retrospectively predict the subsequent relapse