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Hematologic Profile and Lymphocyte Subpopulations in Hemoglobin SC disease: Comparison With Hemoglobin SS and Black Controls
Author(s) -
Wong WingYen,
Powars Darleen R.,
Operskalski Eva A.,
Mosley James W.,
Hassett Joseph,
Zhou Yi
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/1096-8652(199607)52:3<150::aid-ajh2830520302>3.0.co;2-6
Subject(s) - monocytosis , granulocytosis , hemoglobin , medicine , eosinopenia , lymphocyte , immunology , leukocytosis , platelet , gastroenterology , granulocyte , bone marrow
Compared with subjects with homozygous SS disease (Hb SS), persons with hemoglobin SC (Hb SC) are known to have a more gradual loss of splenic function, a lower incidence of bacterial infections, and fewer end‐organ failures. We studied hematological indices and lymphocyte subpopulations of 27 Hb SC subjects and compared them with 173 Hb SS patients and 131 black controls. Hb SC patients had higher hemoglobin levels than Hb SS subjects, lower total leukocyte, granulocyte, monocyte, and lymphocyte counts. Platelets decresed with age but not significantly, instead of incressing as among Hb SS patients. Mononuclerar cells were generally similar to controls with the exception of CD8 + HLA‐DR + counts resembling Hb SS, Hematologic changes in Hb SC are limited to moderate granulocytosis in children and aduts, mild monocytosis in aduts, and increased activation of just one lymphocyte subset among those measured.