Appendix B: Definition of Terms and Lexicon of Clinical Observations in Nonclinical (Animal) Studies

Anesthetized The absence of or reduced response to external stimuli, accompanied with a loss of righting reflex. Ataxia Incoordination of muscular action involving locomotion, including loss of coordination and unsteady gait. Hyperactivity An abnormally high level of motor activity. Hypersensitivity An abnormally strong reaction to external stimuli such as noise or touch. Lethargy A state of deep and prolonged depression stupor from which it is possible to be aroused, followed by an immediate relapse. Low carriage The animal’s torso is carried very close to the ground during movement. Prostrate Animal assumes a recumbent position due to loss of strength or exhaustion and may show intermittent uncoordinated movements. Righting reflex The ability of an animal, when placed on its back, to regain a position on all fours. Unsteady gait An erratic manner or style of walking.