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Preface
Author(s) -
Robinson J. Paul,
Darzynkiewicz Zbiegnew,
Dean Phillip N.,
Dressler Lynn G.,
Rabinovitch Peter S.,
Stewart Carleton C.,
Tanke Hans J.,
Wheeless Leon L.
Publication year - 2012
Publication title -
current protocols in cytometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 26
eISSN - 1934-9300
pISSN - 1934-9297
DOI - 10.1002/0471142956.cyprefs60
Subject(s) - philosophy
Finding proper values of physical parameters in mathematical models is often quite a challenge. While many have gotten away with using just the mathematical symbols when doing science and engineering with pen and paper, the modern world of numerical computing requires each physical parameter to have a numerical value, otherwise one cannot get started with the computations. For example, in the simplest possible transient heat conduction simulation, a case relevant for a real physical material needs values for the heat capacity, the density, and the heat conduction coefficient of the material. In addition, relevant values must be chosen for initial and boundary temperatures as well as the size of the material. With a dimensionless mathematical model, as explained in Chapter 3.2, no physical quantities need to be assigned (!). Not only is this a simplification of great convenience, as one simulation is valid for any type of material, but it also actually increases the understanding of the physical problem. Scaling of differential equations is basically a simple mathematical process, consisting of the chain rule for differentiation and some algebra. The choice of scales, however, is a non-trivial topic, which may cause confusion among practitioners without extensive experience with scaling. How to choose scales is unfortunately not well treated in the literature. Most of the times, authors just state scales without proper motivation. The choice of scales is highly problem-dependent and requires knowledge of the characteristic features of the solution or the physics of the problem. The present notes aim at explaining “all nuts and bolts” of the scaling technique, including choice of scales, the algebra, the interpretation of dimensionless parameters in scaled models, and how scaling impacts software for solving differential equations. Traditionally, scaling was mainly used to identify small parameters in mathematical models, such that perturbation methods based on series expansions in terms of the small parameters could be used as an approximate solution method for differential equations. Nowadays, the greatest practical benefit of scaling is related to running numerical simulations, since scaling greatly simplifies the choice of values for the input data and makes the sim-

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