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1,3,4(2 H )‐Isoquinolinetriones: evaluation of amino‐substituted derivatives as redox mediator herbicides
Author(s) -
Mitchell Glynn,
Clarke Eric D,
Ridley Stuart M,
Bartlett David W,
Gillen Kevin J,
Vohra Shaheen K,
Greenhow Daren T,
Ormrod John C,
Wardman Peter
Publication year - 2000
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/(sici)1526-4998(200002)56:2<120::aid-ps112>3.0.co;2-v
Subject(s) - agrochemical , research centre , library science , biology , ecology , agriculture , computer science
Abstract Amino‐substituted derivatives of 2‐ethyl‐1,3,4(2 H )‐isoquinolinetrione have been prepared with the aim of enhancing their hydrolytic stabilities relative to other isoquinolinetriones, and hence potentially improving their herbicidal effects. 5‐Amino‐2‐ethyl‐1,3,4(2 H )‐isoquinolinetrione has been shown to be 12 and 8 times more stable towards hydrolysis than the isomeric 7‐ and 8‐amino derivatives, respectively, and 120 times more stable than 2‐ethyl‐1,3,4(2 H )‐isoquinolinetrione itself. Pulse radiolysis studies have shown 5‐amino‐2‐ethyl‐1,3,4(2 H )‐isoquinolinetrione to have free‐radical properties which could enhance the generation of superoxide radicals in plants. The compound is a potent stimulator of the light‐dependent consumption of oxygen at photosystem I in isolated chloroplasts and also shows high activity in isolated leaf discs. Evidence is presented which indicates that the rate of foliar uptake is a major factor affecting herbicidal activity for this compound. © 2000 Society of Chemical Industry