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Deoxycylindrospermopsin, an analog of cylindrospermopsin from Cylindrospermopsis raciborskii
Author(s) -
Norris Ross L.,
Eaglesham Geoffrey K.,
Pierens Greg,
Shaw Glen R.,
Smith Maree J.,
Chiswell Robyn K.,
Seawright Alan A.,
Moore Michael R.
Publication year - 1999
Publication title -
environmental toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.813
H-Index - 77
eISSN - 1522-7278
pISSN - 1520-4081
DOI - 10.1002/(sici)1522-7278(199902)14:1<163::aid-tox21>3.0.co;2-v
Subject(s) - cylindrospermopsin , cylindrospermopsis raciborskii , toxicity , cyanobacteria , biology , toxin , chemistry , toxicology , microbiology and biotechnology , bacteria , organic chemistry , genetics
Cylindrospermopsin (CYN) is a hepatotoxic alkaloid found in the blue–green alga Cylindrospermopsis raciborskii ( C. raciborskii ). Data indicating CYN alone does not account for the toxicity of freeze dried cultures of C. raciborskii have been presented recently. In an attempt to explain these data, we have purified and characterized the structure of an analog of CYN, deoxycylindrospermopsin (deoxy‐CYN). Three mice dosed intraperitoneally (IP) with 0.8 mg/kg of deoxy‐CYN showed no toxicity after 5 days. Comparison with the toxicity of CYN (5 day median lethal dose approximately 0.2 mg/kg IP) and its relative abundance in C. raciborskii suggest deoxy‐CYN does not contribute significantly to the toxicity of C. raciborskii . The additional toxicity of freeze dried C. raciborskii over pure CYN, therefore, remains unexplained. ©1999 John Wiley & Sons, Inc. Environ Toxicol 14: 163–165, 1999