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Local drug delivery of Argatroban from a polymeric‐metallic composite stent reduces platelet deposition in a swine coronary model
Author(s) -
Kruse Kevin R.,
Crowley James J.,
Tanguay JeanFrancois,
Santos Renato M.,
Millare Debbie Sanders,
Phillips Harry R.,
Zidar James P.,
Stack Richard S.
Publication year - 1999
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/(sici)1522-726x(199904)46:4<503::aid-ccd25>3.0.co;2-3
Subject(s) - argatroban , stent , medicine , thrombus , platelet , coronary stent , platelet activation , cardiology , biomedical engineering , restenosis , thrombin
Thrombus formation after intracoronary stent implantation provides a stimulus for neointimal hyperplasia and if excessive can result in stent thrombosis. We tested the hypothesis that local delivery of an antithrombin drug from a polymeric‐metallic stent inhibits platelet thrombus formation. An uncoated metal slotted tube, a jellyroll slotted metal stent with an Argatroban‐loaded polymeric sleeve, and a jellyroll slotted metal stent with a drug‐leached polymeric sleeve were randomly deployed into the coronary arteries of eight juvenile farm swine. Platelet deposition in the stented segments was determined at 2 hr using autologous 111 Indium oxime‐labeled platelets. Platelet deposition was significantly less in the Argatroban‐loaded stents compared to the Argatroban‐leached stents (1.40 × 10 8 platelets/cm 2 vs. 26.8 × 10 8 platelets/cm 2 ; P = 0.005). When corrected for differences in the metal surface area exposed to blood, platelet deposition was significantly lower in the Argatroban‐loaded stent (1.74 ± 1.95 × 10 8 /cm 2 ) compared to the Argatroban‐leached stent (33.5 ± 39.1 × 10 8 /cm 2 ; P = 0.005) and the uncoated metal stent (36.2 ± 73.3 × 10 8 /cm 2 ; P = 0.006). In this coronary stent thrombosis model Argatroban has local antithrombotic properties when delivered with a polymer‐metallic stent. Improved polymeric designs may reduce risk of thrombus deposition at the site of stent implantation. Cathet. Cardiovasc. Intervent. 46:503–507, 1999. © 1999 Wiley‐Liss, Inc.