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Chiral electrokinetic chromatography using dipeptide polymeric surfactants: Present state of the art
Author(s) -
Haddadian Fereshteh,
Shamsi Shahab A.,
Warner Isiah M.
Publication year - 1999
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/(sici)1522-2683(19991001)20:15/16<3011::aid-elps3011>3.0.co;2-#
Subject(s) - dipeptide , electrokinetic phenomena , micellar electrokinetic chromatography , chromatography , chemistry , electrophoresis , amino acid , biochemistry
Polymeric amino acid based surfactants have been recently employed as pseudostationary phases in capillary electrophoresis. These phases are effective for chiral separation of analytes in different charge states and hydrophobicities. This review paper focuses on polymeric dipeptide surfactants. The benefits of dipeptide over single amino acid micelle polymers are shown. Some aspects of dipeptide surfactants that are presented here includes the amino acid order, effect of number and position of chiral centers, and steric factors on enantiomeric separation of chiral compounds in different charge states. In addition, the preferential site of interaction of the chiral analyte using diastereomers of polymeric dipeptide surfactants is discussed.