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Validation of the HumDXS6807 short tandem repeat polymorphism for forensic application
Author(s) -
Edelmann Jeanett,
Szibor Reinhard
Publication year - 1999
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/(sici)1522-2683(19991001)20:14<2844::aid-elps2844>3.0.co;2-d
Subject(s) - genetics , microsatellite , loss of heterozygosity , allele , biology , variable number tandem repeat , polymorphism (computer science) , str multiplex system , population , allele frequency , tandem repeat , gene , demography , genome , sociology
This paper presents sequence and population genetic data of the HumDXS6807 short tandem repeat (also known as CHLC.GATA52B03) which is a tetranucleotide repeat polymorphism representing seven alleles of 251—275 bp in length. HumDXS6807 is located at Xpter‐Xp22.2, i.e. , at a genetic distance of more than 87 and 151 cM from the well‐known markers HumARA and HumHPRTB, respectively. Kinship tests in 157 family trios revealed a typical X‐linked codominant inheritance; mutations were not found. Population genetic data were obtained by analyzing a Caucasian population sample comprising 308 females and 209 males: polymorphism information content (PIC) = 0.640; Heterozygosity (Het) = 0.668; Mean exclusion chance (MEC) = 0.414. The HumDXS6807 allele distribution met the Hardy‐Weinberg expectations.