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Enantiomeric purity determination of propranolol by capillary electrophoresis using dual cyclodextrins and a polyacrylamide‐coated capillary
Author(s) -
Assi Khaled A.,
Clark Brian J.,
Altria Kevin D.
Publication year - 1999
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/(sici)1522-2683(19990901)20:13<2723::aid-elps2723>3.0.co;2-o
Subject(s) - capillary electrophoresis , chromatography , cyclodextrin , capillary action , chemistry , enantiomer , impurity , polyacrylamide , capillary electrochromatography , linearity , analytical chemistry (journal) , materials science , organic chemistry , physics , quantum mechanics , polymer chemistry , composite material
The use of a chirally selective capillary electrophoresis method is reported for the enantioselective purity determination of propranolol drug substance. The method employed a combination of both charged and neutral cyclodextrin. An internally coated capillary was used to suppress electroosmotic flow and potential peak tailing. The method was capable of monitoring below 0.1% m/m of the undesired impurity. Acceptable validation data was also obtained for recovery, linearity, and for both short and long‐term injection precision.