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Designed combination of chiral selectors for adjustment of enantioseparation selectivity in capillary electrophoresis
Author(s) -
Fillet Marianne,
Chankvetadze Bezhan,
Crommen Jacques,
Blaschke Gottfried
Publication year - 1999
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/(sici)1522-2683(19990901)20:13<2691::aid-elps2691>3.0.co;2-s
Subject(s) - capillary electrophoresis , analyte , selectivity , enantiomer , cyclodextrin , chemistry , chromatography , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
In this study an attempt has been made to explain the reasons for changing the enantioseparation selectivity in some dual cyclodextrin (CD) systems compared to the use of single chiral selectors in capillary electrophoresis (CE). An explanation for selectivity changes is proposed based on the effect of the chiral selector on the mobility of the analyte. In order to support the proposed mechanism, several dual systems were designed on the basis of the known recognition pattern of enantiomers for individual CDs. In most cases the separation selectivity could be adjusted in a designed way. There was no experimental evidence for simultaneous binding of a given chiral analyte with both chiral selectors or of chiral recognition of an analyte complex with one CD by another CD.