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Cyclodextrins as chiral selectors in capillary electrophoresis: A comparative study for the enantiomeric separation of some beta‐agonists
Author(s) -
AboulEnein Hassan Y.,
Efstatiade Mihnea D.,
Baiulescu George E.
Publication year - 1999
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/(sici)1522-2683(19990901)20:13<2686::aid-elps2686>3.0.co;2-0
Subject(s) - capillary electrophoresis , enantiomer , chemistry , chromatography , terbutaline , cyclodextrin , clenbuterol , organic chemistry , medicine , asthma
A comparative study for the enantiomeric separation of terbutaline, clenbuterol, salbutamol and dobutamine was performed by capillary electrophoresis using cyclodextrins and their derivatives as chiral selectors. Several parameters such as buffer composition and temperature were studied. Simple, fast and reliable enantioseparations were achieved for all drugs studied, especially when the isomerically pure sulfated β‒cyclodextrin derivatives were used as chiral selectors.