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Chiral separation of sympathomimetics by ligand exchange capillary electrophoresis
Author(s) -
Schmid Martin G.,
Laffranchini Maria,
Dreveny Dieter,
Gübitz Gerald
Publication year - 1999
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/(sici)1522-2683(19990801)20:12<2458::aid-elps2458>3.0.co;2-8
Subject(s) - sympathomimetics , capillary electrophoresis , chemistry , chromatography , ligand (biochemistry) , receptor , biochemistry , pharmacology , biology
A rapid and simple approach to the chiral separation of sympathomimetic drugs with amino alcohol structure by ligand exchange capillary electrophoresis is described. An N ‒(2‒hydroxyoctyl)‒ L ‒4‒hydroxyproline/copper(II) complex is used as chiral selector. Thirteen sympathomimetics were resolved, nine with baseline resolution. The influence of pH and composition of the electrolyte on resolution was investigated. The optimal pH for complexation of these amino alcohols was found to be 12.