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Capillary zone electrophoresis determination of galanthamine in biological fluids and pharmaceutical preparatives: Experimental design and artificial neural network optimization
Author(s) -
Pokorná Lenka,
Revilla Alma,
Havel Josef,
Patočka Jiří
Publication year - 1999
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/(sici)1522-2683(19990701)20:10<1993::aid-elps1993>3.0.co;2-5
Subject(s) - capillary electrophoresis , chromatography , chemistry , cholinesterase , magnesium , biology , pharmacology , organic chemistry
Galanthamine is a third‐generation cholinesterase inhibitor used against Alzheimer's disease. New analytical methods for the determination of galanthamine in pharmaceutical preparatives and biological fluids, such as urine and serum, were developed. An experimental design and artificial neural network approach were used for method optimization. Thirty‐five ppb of galanthamine were determined in serum samples (with addition of 10 m M magnesium chloride and using solid‐phase preconcentration).