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Y‐chromosome and mitochondrial DNA polymorphisms in Indian populations
Author(s) -
Thangaraj Kumarasamy,
Ramana Gutala V.,
Singh Lalji
Publication year - 1999
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/(sici)1522-2683(19990101)20:8<1743::aid-elps1743>3.0.co;2-v
Subject(s) - genetics , biology , mitochondrial dna , alu element , haplotype , microsatellite , hypervariable region , y chromosome , population , d loop , mtdna control region , allele , population genetics , evolutionary biology , gene , genome , human genome , demography , sociology
Y‐chromosome polymorphism using short tandem repeat (STR) markers on 94 normal males belonging to the Brahmin and Kamma caste populations of Andhra Pradesh, India, and Siddis, a migrant population from Africa, inhabiting Hyderabad, India, revealed heterogeneity as indicated by network analysis. We have observed population‐specific haplotypes and alleles. Analysis of Y‐ Alu polymorphism (YAP) in Siddis showed the presence of Alu insertion in 40% of the individuals. However, YAP insertion was not found in Brahmins and Kammas. The dendrogram based on hypervariable region I (HVR I) of the displacement loop (D‐loop) sequence of mitochondrial DNA (mtDNA) of Siddis showed genetic relationships to African populations. YAP and mtDNA analysis of Siddis also confirmed their immigration from Africa.