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Chiral resolution of atropine, homatropine and eight synthetic tropinyl and piperidinyl esters by capillary zone electrophoresis with cyclodextrin additives
Author(s) -
Jin Lian Ji,
Wang Yan,
Xu Rong,
Go Mei Lin,
Lee Hian Kee,
Li Sam F. Y.
Publication year - 1999
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/(sici)1522-2683(19990101)20:1<198::aid-elps198>3.0.co;2-7
Subject(s) - capillary electrophoresis , enantiomer , chemistry , cyclodextrin , chromatography , atropine , resolution (logic) , organic chemistry , anesthesia , medicine , artificial intelligence , computer science
Chiral resolution of atropine, homatropine and eight synthetic tropinyl and piperidinyl esters were studied by capillary zone electrophoresis with cyclodextrin additives. Atropine and eight synthetic derivatives were successfully resolved by heptakis‐(2,3,6‐tri‐ O ‐methyl)‐β‐cyclodextrin (TM‐β‐CD) at concentrations ranging from 10 to 40 m M . Homatropine was baseline resolved by 10 m M β‐cyclodextrin and hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD), respectively. The developed method was employed for the determination of atropine enantiomers in human serum.