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A New Potent Antifungal `Quinone Methide' Diterpene with a Cassane Skeleton from Bobgunnia madagascariensis
Author(s) -
Schaller Frédéric,
Rahalison Lila,
Islam Nurul,
Potterat Olivier,
Hostettmann Kurt,
StoeckliEvans Helen,
Mavi Steven
Publication year - 2000
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/(sici)1522-2675(20000216)83:2<407::aid-hlca407>3.0.co;2-v
Subject(s) - quinone methide , chemistry , diterpene , antifungal , bark (sound) , candida albicans , stereochemistry , quinone , skeleton (computer programming) , botany , microbiology and biotechnology , biology , physics , computer science , acoustics , programming language
A new `quinone methide' diterpene with a cassane skeleton was isolated from the root bark of Bobgunnia madagascariensis ( Desv. ) J.H. Kirkbr. et Wiersema (Leguminosae). Its structure was established as (4b S ,8a S )‐4b,5,6,7,8,8a‐hexahydro‐4‐hydroxy‐2‐(2‐hydroxyethyl)‐1,4b,8,8‐tetramethylphenanthrene‐3,9‐dione by spectroscopic methods including single‐crystal X‐ray analysis. This compound showed strong antifungal properties towards human pathogenic fungi, in particular the yeast Candida albicans.