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Stepwise Solid‐Phase Synthesis of Peptide‐Oligonucleotide Conjugates on New Solid Supports
Author(s) -
Antopolsky Maxim,
Azhayev Alex
Publication year - 1999
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/(sici)1522-2675(19991215)82:12<2130::aid-hlca2130>3.0.co;2-a
Subject(s) - chemistry , phosphodiester bond , oligonucleotide , peptide , solid phase synthesis , conjugate , combinatorial chemistry , peptide synthesis , stereochemistry , biochemistry , dna , rna , gene , mathematical analysis , mathematics
Several peptide‐oligonucleotide and peptide‐(oligonucleotide phosphorothioate) conjugates were synthesized on new solid supports. These supports are designed to link the 3′‐terminus of an oligonucleotide to the C‐end of a peptide via a phosphodiester or phosphorothioate bond in the process of stepwise solid‐phase assembly.