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Macrocyclic Spermine Alkaloids from Verbascum: The ( E / Z )‐Isomeric Pairs (−)‐( S )‐Verbasitrine/(−)‐( S )‐Isoverbasitrine and (+)‐( S )‐Verbametrine/(+)‐( S )‐Isoverbametrine: Isolation, Structure Elucidation, and Synthesis
Author(s) -
Drandarov Konstantin,
Guggisberg Armin,
Hesse Manfred
Publication year - 1999
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/(sici)1522-2675(19990210)82:2<229::aid-hlca229>3.0.co;2-h
Subject(s) - chemistry , spermine , stereochemistry , isolation (microbiology) , organic chemistry , biology , enzyme , microbiology and biotechnology
The isolation and structure elucidation of the 17‐membered macrocyclic spermine alkaloids (−)‐( S )‐verbasitrine ( 2 ), (−)‐( S )‐isoverbasitrine ( 4 ), (+)‐( S )‐verbametrine ( 6 ), and (+)‐( S )‐isoverbametrine ( 8 ) is presented. The synthesis of their racemates is described.