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The Utility of Capped Duplex DNA ( σ ‐DNA) in Triplex Interaction Studies
Author(s) -
Bannwarth Willi,
Iaiza Patrick
Publication year - 1998
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/(sici)1522-2675(19981007)81:10<1739::aid-hlca1739>3.0.co;2-5
Subject(s) - chemistry , dna , duplex (building) , rna , molecule , biophysics , stereochemistry , biochemistry , gene , organic chemistry , biology
Two optimally capped duplex DNA molecules ( σ ‐DNA; see 1 and 4 ) were synthesized and their utility demonstrated for triplex investigations with their corresponding homopyrimidine DNA and RNA single strands in the D⋅(D⋅D) and R⋅(D⋅D) Hoogsteen mode. Furthermore, it was established that σ ‐DNA is an ideal tool to study the pH dependency of triplex formation.