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Libraries via Metathesis of Internal Olefins
Author(s) -
Brändli Christof,
Ward Thomas R.
Publication year - 1998
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/(sici)1522-2675(19980909)81:9<1616::aid-hlca1616>3.0.co;2-p
Subject(s) - chemistry , olefin metathesis , metathesis , catalysis , salt metathesis reaction , oleic acid , organic chemistry , olefin fiber , acyclic diene metathesis , grubbs' catalyst , ring opening metathesis polymerisation , molecule , medicinal chemistry , polymerization , biochemistry , polymer
The cross‐metathesis of internal olefins is applied for the combinatorial synthesis of small organic molecules; this reaction is conveniently carried out in neat olefin (oleic‐acid derivatives) and requires only 0.001 equiv. of [Ru(CHPh)Cl 2 (PCy 3 ) 2 ] as catalyst (Cy = cyclohexyl).