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Contribution of trifluoperazine metabolites to the in vivo 19 F NMR spectrum of rat brain
Author(s) -
Lindquist Diana M.,
Dachtler Markus,
Hawk Roger M.,
Karson Craig N.,
Albert Klaus,
Komoroski Richard A.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(200005)43:5<756::aid-mrm19>3.0.co;2-u
Subject(s) - trifluoperazine , in vivo , chemistry , in vitro , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , metabolite , fluorine 19 nmr , stereochemistry , biochemistry , biology , enzyme , calmodulin , physics , microbiology and biotechnology
Fluorine‐19 NMR spectra were acquired from extracts of tissues from heads of rats given the antipsychotic drug trifluoperazine (TFP). Contributions to the in vivo 19 F spectra from tissues other than brain were negligible. The in vivo 19 F resonance at ‐62.3 ppm from CCl 3 F consisted of 6–8 resolved resonances in vitro. Some in vitro resonances were assigned to previously identified TFP metabolites. Multiple resonances in vitro partially explain the relatively large line width seen in vivo for TFP. Unidentified metabolites were observed at about ‐74 to ‐75 ppm in a number of spectra of extracts of brain and muscle. Magn Reson Med 43:756–759, 2000. © 2000 Wiley‐Liss, Inc.