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Spatial and temporal evolution of hemorrhage in the hyperacute phase of experimental spinal cord injury: In vivo magnetic resonance imaging
Author(s) -
Bilgen Mehmet,
Abbe Russell,
Liu ShiJie,
Narayana Ponnada A.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(200004)43:4<594::aid-mrm15>3.0.co;2-1
Subject(s) - magnetic resonance imaging , edema , spinal cord injury , white matter , medicine , spinal cord , in vivo , nuclear medicine , cord , anatomy , radiology , surgery , biology , microbiology and biotechnology , psychiatry
To follow the spatial and temporal evolution of hemorrhage, in vivo MRI studies of experimental spinal cord injury (SCI) were performed on 17 rats in the very acute phase (hyperacute), starting as early as 9 min and continued up to 400 min posttrauma. Axial MR images were processed slice by slice over a 21 mm length around the epicenter of the injury. The data were analyzed statistically and fitted to an empirically derived function to characterize the spatial and temporal evolution of hemorrhage. The results indicated that 1) the initial hemorrhage in the very early phase of the injury area covered 12.5% of the total cord area and subsequently increased with a time constant of 700 min, 2) a major portion of the hemorrhage was concentrated spatially within the 4 mm distance from the epicenter, 3) the volume of hemorrhage normalized to its initial value increased linearly at a rate of approximately 0.0015 min −1 , and 4) edema was observed at the gray‐ and white‐matter junction as early as 12 min postinjury. In general, edema appeared to be focal and scattered in this phase of the injury, which made its quantification unreliable on MRI. Magn Reson Med 43:594–600, 2000. © 2000 Wiley‐Liss, Inc.