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Surface‐coil polarization transfer for monitoring tissue metabolism in vivo
Author(s) -
Payne G.S.,
Leach M.O.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(200004)43:4<510::aid-mrm4>3.0.co;2-5
Subject(s) - polarization (electrochemistry) , spins , specific absorption rate , nuclear magnetic resonance , in vivo , electromagnetic coil , adiabatic process , chemistry , materials science , optics , physics , computer science , condensed matter physics , microbiology and biotechnology , telecommunications , quantum mechanics , antenna (radio) , biology , thermodynamics
Polarization transfer methods can substantially enhance NMR signals from nuclei of low γ, which are J‐coupled to nuclei of high γ, but to date have had limited application for in vivo 31 P MRS studies. They require both accurate flip angles and good localization in order to achieve their potential. Described here is an implementation of the insensitive nuclei enhanced by polarization transfer (INEPT) polarization transfer method using segmented adiabatic BIR4 RF pulses. Localization uses ISIS, applied to the coupled 1 H spins. Detailed analysis is performed to evaluate the specific absorption rate power deposition when using surface coils. Polarization transfer, localization capability, and use with surface coils are demonstrated using suitable test objects. Finally, in vivo data are presented from the liver of a normal volunteer in which the signals from the phosphodiester peaks are substantially enhanced. Magn Reson Med 43:510–516, 2000. © 2000 Wiley‐Liss, Inc.