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In vivo intravoxel incoherent motion measurements in the human placenta using echo‐planar imaging at 0.5 T
Author(s) -
Moore R.J.,
Issa B.,
Tokarczuk P.,
Duncan K.R.,
Boulby P.,
Baker P.N.,
Bowtell R.W.,
Worthington B.S.,
Johnson I.R.,
Gowland P.A.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(200002)43:2<295::aid-mrm18>3.0.co;2-2
Subject(s) - intravoxel incoherent motion , echo planar imaging , nuclear magnetic resonance , human placenta , diffusion , spin echo , reproducibility , placenta , noise (video) , nuclear medicine , physics , materials science , diffusion mri , mathematics , magnetic resonance imaging , medicine , image (mathematics) , computer science , radiology , fetus , statistics , biology , pregnancy , genetics , thermodynamics , artificial intelligence
This paper presents the first in vivo measurements of intravoxel incoherent motion in the human placenta, obtained using the pulsed gradient spin echo (PGSE) sequence. The aims of this study were two‐fold. The first was to provide an initial estimate of the values of the IVIM parameters in this organ, which are currently unknown. The second aim was then to use these results to optimize the sequence timings for future studies. The moving blood fraction (f), diffusion coefficient (D), and pseudo‐diffusion coefficient (D*) were measured. The average value of f was 26 ± 6 % (mean ± SD), D was 1.7 ± 0.5 × 10 −3 mm 2 /sec, and D* was 57 ± 41 × 10 −3 mm 2 /sec. For the optimized values of b, the expected percentage uncertainty in the fitted values of f, D, and D* for the placenta were σf/f = 14.9%, σD/D = 14.3%, σD*/D* = 44.9%, for an image signal‐to‐noise of 20:1, and a total imaging time of 800 sec. Magn Reson Med 43:295–302, 2000. © 2000 Wiley‐Liss, Inc.