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A model of unloaded human intervertebral disk based on NMR relaxation
Author(s) -
Nightingale Teresa,
MacKay Alex,
Pearce Richard H.,
Whittall Kenneth P.,
Flak Borys
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(200001)43:1<34::aid-mrm5>3.0.co;2-7
Subject(s) - residue (chemistry) , proteoglycan , chemistry , glycosaminoglycan , intervertebral disk , nucleus , nuclear magnetic resonance , t2 relaxation , intervertebral disc , biophysics , anatomy , biochemistry , magnetic resonance imaging , extracellular matrix , biology , physics , medicine , radiology , lumbar , microbiology and biotechnology
NMR relaxation rates were related to the composition of the nucleus pulposus from 11 and anulus fibrosus from six human intervertebral disks. Tissue water was proportional to glycosaminoglycan (GAG) and residue, the noncollagen, non‐GAG portion of the dry weight ( R 2 = 0.74). The solid signal fraction depended on collagen and residue protons ( R 2 = 0.89). 1/T 1 was proportional to collagen and residue ( R 2 = 0.97). T 2 showed 2–4 components labeled A, B, C, and D, with means ± standard deviations of 3.1 ± 1.6, 17.5 ± 9.5, 64 ± 22, and 347 ± 162 msec. Signal fractions of A and B depended on the collagen‐associated water protons ( R 2 = 0.94 and 0.85), C on residue‐associated water protons ( R 2 = 0.82), and D on GAG‐associated water protons ( R 2 = 0.74). The data led to a model of disk architecture in which the collagen and residue were largely solid, forming distinct water compartments; the remaining water was present in a proteoglycan gel. Magn Reson Med 43:34–44, 2000. © 2000 Wiley‐Liss, Inc.