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In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model
Author(s) -
Mahankali Srikanth,
Liu Yijun,
Pu Yonglin,
Wang Janey,
Chen ChunWen,
Fox Peter T.,
Gao JiaHong
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(200001)43:1<155::aid-mrm20>3.0.co;2-5
Subject(s) - intraperitoneal injection , hypothalamus , in vivo , endocrinology , medicine , animal model , nuclear medicine , anesthesia , biology , microbiology and biotechnology
The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague‐Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid‐sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T 2 *‐weighted gradient‐echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4%) in the hypothalamic region within 12–16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications. Magn Reson Med 43:155–159, 2000. © 2000 Wiley‐Liss, Inc.