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Absolute measurements of water content using magnetic resonance imaging: Preliminary findings in an in vivo focal ischemic rat model
Author(s) -
Venkatesan R.,
Lin W.,
Gurleyik K.,
He Y.Y.,
Paczynski R.P.,
Powers W.J.,
Hsu C.Y.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(200001)43:1<146::aid-mrm18>3.0.co;2-l
Subject(s) - in vivo , magnetic resonance imaging , nuclear magnetic resonance , content (measure theory) , chemistry , pathology , medicine , radiology , physics , biology , mathematics , mathematical analysis , microbiology and biotechnology
Using a magnetic resonance (MR) imaging method, absolute measurements of in vivo brain water content were obtained in 15 male Long Evans rats that underwent a 90‐min focal cerebral ischemia. A strong linear relationship (r = 0.80) with a slope of 1 was observed when correlating MR‐measured water content to that obtained with the ex vivo wet/dry measurements. This effective spin‐density‐based method is the first‐reported in vivo absolute quantification of brain tissue water content associated with a pathophysiological state and preliminary findings suggest that a noninvasive measurement of brain water content can be obtained with MRI. Magn Reson Med 43:146–150, 2000. © 2000 Wiley‐Liss, Inc.