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Perfusion‐based event‐related functional MRI
Author(s) -
Liu HoLing,
Gao JiaHong
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199912)42:6<1011::aid-mrm3>3.0.co;2-r
Subject(s) - perfusion , functional magnetic resonance imaging , visual cortex , hemodynamics , stimulus (psychology) , stimulation , perfusion scanning , magnetic resonance imaging , blood oxygenation , blood flow , medicine , neuroscience , cardiology , nuclear magnetic resonance , nuclear medicine , psychology , radiology , physics , psychotherapist
Perfusion‐based event‐related functional MRI was performed by measuring flow‐sensitive alternating inversion recovery (FAIR) signal changes during repeated single‐trial, short visual stimulation (250 msec). In the visual cortex activation area, the blood flow increases immediately after the stimulus, reaches the maximum 4 sec later with a perfusion‐sensitized signal change of 16.1 ± 2.6 %, and then decreases to baseline approximately 11 sec after the stimuli. As it is a more direct reflection of the hemodynamic response, perfusion‐based event‐related functional MRI techniques may be more useful for human cognitive function studies, compared with blood oxygenation level–dependent (BOLD)‐based event‐related functional MRI techniques. Magn Reson Med 42:1011–1013, 1999. © 1999 Wiley‐Liss, Inc.