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Effects of blood sugar level on rat transient focal brain ischemia consecutively observed by diffusion‐weighted EPI and 1 H echo planar spectroscopic imaging
Author(s) -
Morikawa Shigehiro,
Inubushi Toshiro,
Ishii Hisanari,
Nakasu Yoko
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199911)42:5<895::aid-mrm9>3.0.co;2-r
Subject(s) - ischemia , effective diffusion coefficient , medicine , saline , anesthesia , magnetic resonance imaging , radiology
The effects of blood sugar level on transient focal brain ischemia were examined by consecutive diffusion‐weighted EPI and 1 H echo planar spectroscopic imaging. A remote‐controlled rat intraluminal suture middle cerebral artery occlusion (MCAO) model was prepared. Animals were divided into three experimental groups: control, 1 g/kg, and 2 g/kg glucose groups (n = 6 for each). Saline or glucose was infused intraperitoneally 30 min prior to MCAO. The glucose‐loaded groups showed increased lactate accumulation and marked decreases in average diffusion coefficient in the ischemic region during 40‐min MCAO. These changes were correlated with blood sugar levels at the onset of MCAO. After reperfusion, all rats in the control and 1 g/kg groups recovered from the ischemic changes, but three rats with marked hyperglycemia in the 2 g/kg group showed irreversible changes. The adverse effects of hyperglycemia on transient focal brain ischemia were clearly demonstrated by sequential 2D images. Magn Reson Med 42:895–902, 1999. © 1999 Wiley‐Liss, Inc.