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Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: The deoxyhemoglobin dilution model
Author(s) -
Hoge Richard D.,
Atkinson Jeff,
Gill Brad,
Crelier Gérard R.,
Marrett Sean,
Pike G. Bruce
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199911)42:5<849::aid-mrm4>3.0.co;2-z
Subject(s) - cerebral blood flow , nuclear magnetic resonance , chemistry , blood flow , visual cortex , hypercapnia , dilution , magnetic resonance imaging , residual , blood oxygen level dependent , oxygen , nuclear medicine , cardiology , neuroscience , mathematics , physics , medicine , psychology , thermodynamics , radiology , organic chemistry , algorithm , respiratory system
The relationship between blood oxygenation level‐dependent (BOLD) MRI signals, cerebral blood flow (CBF), and oxygen consumption (CMR O2 ) in the physiological steady state was investigated. A quantitative model, based on flow‐dependent dilution of metabolically generated deoxyhemoglobin, was validated by measuring BOLD signals and relative CBF simultaneously in the primary visual cortex (V1) of human subjects ( N = 12) during graded hypercapnia at different levels of visual stimulation. BOLD and CBF responses to specific conditions were averaged across subjects and plotted as points in the BOLD‐CBF plane, tracing out lines of constant CMR O2 . The quantitative deoxyhemoglobin dilution model could be fit to these measured iso‐CMR O2 contours without significant ( P ≤ 0.05) residual error and yielded MRI‐based CMR O2 measurements that were in agreement with PET results for equivalent stimuli. BOLD and CBF data acquired during graded visual stimulation were then substituted into the model with constant parameters varied over plausible ranges. Relative changes in CBF and CMR O2 appeared to be coupled in an approximate ratio of ∼2:1 for all realistic parameter settings. Magn Reson Med 42:849–863, 1999. © 1999 Wiley‐Liss, Inc.