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Coronary venous oximetry using MRI
Author(s) -
Foltz Warren D.,
Merchant Naeem,
Downar Eugene,
Stainsby Jeff A.,
Wright Graham A.
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199911)42:5<837::aid-mrm3>3.0.co;2-8
Subject(s) - coronary sinus , blood flow , cardiology , medicine , venous blood , dipyridamole , blood sampling , sampling (signal processing) , catheter , coronary flow reserve , radiology , computer science , filter (signal processing) , computer vision
Based on the Fick law, coronary venous blood oxygen measurements have value for assessing functional parameters such as the coronary flow reserve. At present, the application of this measure is restricted by its invasive nature. This report describes the design and testing of a noninvasive coronary venous blood oxygen measurement using MRI, with a preliminary focus on the coronary sinus. After design optimization including a four‐coil phased array and an optimal set of data acquisition parameters, quality tests indicate measurement precision on the order of the gold standard optical measurement (3%O 2 ). Comparative studies using catheter sampling suggest reasonable accuracy (3 subjects), with variability dominated by sampling location uncertainty (∼7%O 2 ). Intravenous dipyridamole (5 subjects) induces significant changes in sinus blood oxygenation (22 ± 9% O 2 ), corresponding to flow reserves of 1.8 ± 0.4, suggesting the potential for clinical utility. Underestimation of flow reserve is dominated by right atrial mixing and the systemic effects of dipyridamole. Magn Reson Med 42:837–848, 1999. © 1999 Wiley‐Liss, Inc.