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Use of T 2 ‐weighted susceptibility contrast MRI for mapping the blood volume in the glioma‐bearing rat brain
Author(s) -
Le Duc Géraldine,
Péoc'h Michel,
Rémy Chantal,
Charpy Odile,
Muller Robert N.,
Le Bas Jean François,
Décorps Michel
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199910)42:4<754::aid-mrm18>3.0.co;2-q
Subject(s) - magnetic resonance imaging , glioma , cerebral blood volume , contrast (vision) , blood volume , nuclear magnetic resonance , brain tumor , in vivo , chemistry , dynamic contrast enhanced mri , nuclear medicine , pathology , medicine , radiology , biology , physics , microbiology and biotechnology , cancer research , optics , cardiology
The aim of this work was to evaluate the potential of T 2 ‐weighted, steady‐state susceptibility‐enhanced contrast magnetic resonance imaging (MRI), to characterize brain tumor heterogeneity and tumor vascularization. In vivo T 2 ‐weighted MRI experiments were carried out on normal rats ( n = 11) and rats bearing C6 glioma ( n = 17), before and after the injection of a remanent superparamagnetic contrast agent. The Δ R 2 variations of the transverse relaxation rate due to the injection of the contrast agent were used to generate relative cerebral blood volume (CBV) maps. Contrast enhancement of the tumor was shown to reflect tissue vascularization rather than leakage of the blood‐brain barrier. The quantitative results clearly show the heterogeneity of tumor vascularization and reveal a high vessel density in the peripheral area (CBV per ∝ 17.2 ± 2.3 sec −1 ) and a low vessel density in the central area of the tumor (CBV cen ∝ 2.5 ± 0.5 sec −1 ). Magn Reson Med 42:754–761, 1999. © 1999 Wiley‐Liss, Inc.