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Accurate and rapid quantitative dynamic contrast‐enhanced breast MR imaging using spoiled gradient‐recalled echoes and bookend T 1 measurements
Author(s) -
Cron Greg O.,
Santyr Giles,
Kelcz Frederick
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199910)42:4<746::aid-mrm17>3.0.co;2-u
Subject(s) - imaging phantom , flip angle , dynamic contrast , gradient echo , dynamic imaging , nuclear magnetic resonance , dynamic range , dynamic contrast enhanced mri , contrast (vision) , magnetic resonance imaging , signal (programming language) , physics , nuclear medicine , computer science , optics , image processing , image (mathematics) , artificial intelligence , medicine , radiology , digital image processing , programming language
A method is presented that converts dynamic T 1 ‐weighted spoiled gradient‐recalled echo (SGRE) image intensities into estimates of T 1 without the errors associated with imperfections in the slice profile and transmitter coil magnetic field ( B 1 ). The method involves T 1 measurements performed before and after a series of dynamic SGRE images. These measurements serve to calibrate and correct the SGRE signal strength equation used to estimate T 1 . Simulations and phantom experiments were performed to test the method for slice‐selective (two‐dimensional) and slab‐selective (three‐dimensional) imaging, as well as for imaging performed with optimized and un‐optimized B 1 . For nearly all test conditions, T 1 was estimated accurately (within 10%) over a range of T 1 values expected in vivo (∼1200 → 300 msec). This method should be useful for quantifying dynamic SGRE imaging for many different applications including breast MR imaging. Magn Reson Med 42:746–753, 1999. © 1999 Wiley‐Liss, Inc.