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Pharmacological modifications of the partial pressure of oxygen in murine tumors: Evaluation using in vivo EPR oximetry
Author(s) -
Gallez Bernard,
Jordan Bénédicte F.,
Baudelet Christine,
Misson PierreDamien
Publication year - 1999
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/(sici)1522-2594(199910)42:4<627::aid-mrm2>3.0.co;2-m
Subject(s) - in vivo , carbogen , electron paramagnetic resonance , vasoactive , oxygen , chemistry , vasodilation , partial pressure , pharmacology , nuclear magnetic resonance , medicine , biology , physics , microbiology and biotechnology , organic chemistry
EPR oximetry using an implantable paramagnetic probe was used to quantify the partial pressure of oxygen (pO 2 ) in tissues in a transplantable mouse tumor model (TLT) after administration of 34 different vasodilators belonging to one of the following classes: angiotensin‐converting enzyme inhibitors, calcium antagonists, alpha antagonists, potassium channel openers, beta‐blockers, NO donors, and peripheral vasoactive agents. Twenty‐four compounds were efficient in significantly increasing the local pO 2 in a majority of tumors. The increase of local pO 2 using pharmacological treatments was lower than that achieved by using oxygen or carbogen breathing. This technique offers an unprecedented tool for rapidly and accurately measuring treatment‐induced modifications of pO 2 in tumors. Magn Reson Med 42:627–630, 1999. © 1999 Wiley‐Liss, Inc.